“In-silico Dyeing strategy: Unveiling the Binding of Cotton Protein Annexin to Phyto-Pigments through Bioinformatics"

Articles in Press

Document Type : Original Article

Authors

1 Dept of Biotechnology, Bapuji Institute of Engg and Technology, Davangere 577004, KArnataka , INDIA

2 Dept of Biotechnology, Bapuji INstitute of Engg and Tehcnology, Davangere, Karnatka, INDIA

Abstract

Natural dyes derived from plant sources such as fruits and flowers offer enhanced biodegradability and environmental compatibility compared to synthetic alternatives. This bioinformatics study explores the in silico interactions of phyto-pigments with cotton-specific proteins, emphasizing their potential applications in the cotton textile industry. Utilizing an integrated bioinformatics approach including molecular docking, virtual screening, and visualization tools such as DS Visualizer, we investigated the binding interactions between phyto-pigments and Annexin, a key cotton protein. A total of seven phyto-pigments were examined: Malvidin, Peonidin, Cyanidin, Petunidin, Pelargonidin, Betanin, and Betacyanin. Among these, Betanin and Betacyanin found in beetroot and dragon fruit, respectively exhibited the strongest binding affinities with Annexin. These pioneer findings from insilico studies suggest a promising role for these bio-pigments in the development of natural dyes with functional biological activity. The elucidation of specific binding modes and structural compatibilities reinforces the value of in silico studies in advancing the application of bio-based dyes for sustainable textile dyeing processes. This bioinformatics study underscores the potential of phyto-pigments not only as eco-friendly colorants but also as agents capable of forming meaningful biochemical interactions within textile fibres.

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Main Subjects

Progress in Color, Colorants and Coatings

Articles in Press, Accepted Manuscript
Available Online from 27 October 2025

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