Corrosion Inhibition Activity of Cefixime on Mild Steel Surface in Aqueous Sulphuric Acid

Document Type : Original Article


Department of Chemistry, Manav Rachna University, Faridabad-221004, Haryana India.


Interaction of pharmaceutically active drug Cefixime on mild steel surface in 0.5 M sulphuric acid solution was studied using gravimetric analysis techniques, Polarization techniques, i.e., Polarization resistance, Tafel polarization, and Electrochemical Impedance Spectroscopy (EIS) techniques. It shows more than 96 % corrosion inhibition efficiency at an ambient temperature of 308 oK on a mild steel surface with a 4.0×10-4 M  inhibitor concentration. Gravimetric studies were also conducted at various temperatures and concentration ranges of the testing solution to justify their range of applicability at different practical conditions. And It is found very much suitable for its workings at the normal temperature and lower acid concentration ranges. Adsorption parameters and thermodynamic parameters were calculated from gravimetric analysis data. These parameters were obtained at different temperatures and concentration ranges and reveal that the inhibitor follows the physical adsorption mechanism. Langmuir's adsorption isotherm governs the adsorption of the cefixime molecule. Inhibition of cefixime on the surface of mild steel is supplemented by atomic force microscopy. The result reveals that the inhibited surface has less roughness than the uninhibited surface.


Main Subjects

  1. K. Singh, S. Kumar, G. Udayabhanu, R. P. John, 4(N,N-dimethylamino) benzaldehyde nicotinic hydrazone as corrosion inhibitor for mild steel in 1 M HCl solution: An experimental and theoretical study, J. Mol. Liquids, 216(2016), 738-746.
  2. K. Alaneme, S. J. Olusegun O. T. Adelowo, Corrosion inhibition and adsorption mechanism studies of Hunteria umbellata seed husk extracts on mild steel immersed in acidic solutions, Alex. Engg. J., 55(2016), 673-681.
  3. A. Ali, M. T. Saeed S. V. Rahman, The isoxazolidines: a new class of corrosion inhibitors of mild steel in acidic medium, Corros. Sci., 45(2003), 253-266,
  4. Xia, G. M. Whitesides, Replica moulding with a polysiloxane mold provides this patterned microstructure, Angew. Chem. Int. Ed., 37(1998), 550-575,
  5. G. Mohamed, A. Mahdi, R. J. Obaid, M. A. Hegazi, S. W. Kuo, K. I. Aly, Synthesis and characterization of polybenzoxazine/clay hybrid nanocomposites for UV light shielding and anti-corrosion coatings on mild steel, J. Polym. Res., 28(2021), 264-276.
  6. G. Mohamed, S. W. Kuo, A. Mahdi, I. M. Ghayd, K. I. Aly, Bisbenzylidene cyclopentanone and cyclohexanone-functionalized polybenzoxazine nano-composites: Synthesis, characterization, and use for corrosion protection on mild steel, Mater. Today Commun., 25(2020), 101418
  7. I. Aly, A. Mahdi, M. A. Hegazi, N. S. Al-Muaikel, S. W. Kuo, M. G. Mohamed, Corrosion resistance of mild steel coated with Phthalimide-Functionalized polybenzoxazines, Coatings, 10(2020), 1114
  8. I. Aly, M. G. Mohamed, O. Younis, M. H. Mahross, M. A. Hakim, M. M. Sayed, Salicylaldehyde azine-functionalized polybenzoxazine: synthesis, characterization, and its nanocomposites as coatings for inhibiting the mild steel corrosion, Prog. Org. Coat., 138 (2020), 105385.
  9. I. Aly, O. Younis, M. H. Mahross, O. Tsutsumi, M. G. Mohamed, M. M. Sayed, Novel conducting polymeric nanocomposites embedded with nanoclay: synthesis, photoluminescence, and corrosion protection performance, Polym. J., 51(2019), 77-90.
  10. K. Shukla, M. A. Quraishi, Cefotaxime sodium: A new and efficient corrosion inhibitor for mild steel in hydrochloric acid solution, Corros. Sci., 51(2009), 1007-1011
  11. A. Chidiebere, E. E. Oguzie, L. Liu, Y. Li, F. Wang, Adsorption and corrosion inhibiting effect of riboflavin on Q235 mild steel corrosion in acidic environments, Mater. Chem. Phys., 156(2015), 95-104
  12. Roy, P. Karfa , U. Adhikari, D. Sukul , Corrosion inhibition of mild steel in acidic medium by polyacrylamide grafted Guar gum with various grafting percentage: Effect of intramolecular synergism, Corros. Sci., 88(2014), 246-253
  13. Abdallah, Antibacterial drugs as corrosion inhibitors for corrosion of aluminium in hydrochloric solution, Corros. Sci., 46 (2004), 1981-1996.
  14. Y. Feng, S. H. Chen, W. J. Guo, Y. X. Zhang, G. Z. Liu, Inhibition of iron corrosion by 5,10,15,20-tetraphenylporphyrin and 5, 10, 15, 20-tetra-(4-chlorophenyl) porphyrin adlayers in 0.5 M H2SO4 solutions, J. Electroanal. Chem., 602(2007), 115-122.
  15. J. Guo, S. H. Chen, Y. Y. Feng, C. J. Yang, Investigations of triphenyl phosphate and bis-(2-ethylhexyl) phosphate self-assembled films on iron surface using electrochemical methods, fourier transform infrared spectroscopy, and molecular simulations, J. Phy. Chem., 111(2007), 3109-3115.
  16. A. Ali, M. T. Saeed, S. V. Rahman , The isoxazolidines: A new class of corrosion inhibitors of mild steel in acidic medium, Corros. Sci., 45(2003), 253-266.
  17. Lagrenee, B. Mernari, M. Bouanis, M. Traisnel, F. Bentiss, Study of the mechanism and inhibiting efficiency of 3,5-bis(4-methylthiophenyl)-4H-1,2,4-triazole on mild steel corrosion in acidic media, Corros. Sci., 44(2002), 573-588.
  18. A. Quraishi, R. Sardar, Aromatic triazoles as corrosion inhibitors for mild steel in acidic environments, Corrosion, 58(2002), 748-755.
  19. A. Quraishi, M. Athar, H. Ali, Corrosion inhibition of carbon steel in hydrochloric acid by organic compounds containing heteroatoms, Corrosion J., 37(2002). 155-158.
  20. A. Quraishi, , F. A Ansari, Corrosion inhibition by fatty acid triazoles for mild steel in formic acid, J. Appl. Electrochem., 33(2003), 233-238.
  21. M A. Quraishi., S. Khan, Inhibition of mild steel corrosion in sulfuric acid solution by thiadiazoles, Appl. Electrochem., 36(2006), 539-544.
  22. A. Quraishi, I.Ahmad, A. K.Singh, S. K.Shukla, B. Lal, V.Singh, N-(Piperidinomethyl)-3-[(pyridylidene) amino]isatin: A new and effective acid corrosion inhibitor for mild steel, Mater. Chem. Phys., 112(2008), 1035-1039.
  23. Bentiss, M. Lagrenee, M. Traisnel, J. C. Hornez, The corrosion inhibition of mild steel in acidic media by a new triazole derivative, Corros. Sci., 41(1999), 789-803.
  24. B. Growcock, W. W. Frenier, P. A Andreozzi, Inhibition of steel corrosion in HCl by derivatives of cinnamaldehyde: Part II. structure–activity correlations, Corrosion, 45(1989), 1007-1015, .
  25. Lukovits, E. Kalman, G. Palinkas, Nonlinear group-contribution models of corrosion inhibition, Corrosion, 51(1995), 201-205.
  26. C. Ayers, J. N. Hackerman, Corrosion inhibition in HCl using methyl pyridines, J. Electrochem. Soc., 110(1963), 507-512.
  27. K. Shukla, M. A. Quraishi, R. Prakash, A self-doped conducting polymer polyanthranilic acid: An efficient corrosion inhibitor for mild steel in acidic solution Corrosion Science, Corros. Sci., 50(2008), 2867-2872.
  28. A. Quraishi, S. K. Shukla, Poly(aniline-formaldehyde): A new and effective corrosion inhibitor for mild steel in hydrochloric acid, Mater. Chem. Phys., 113(2008), 685-689,
  29. Moretti, F. Guidi, G. Grion, Tryptamine as a green iron corrosion inhibitor in 0.5 M deaerated sulphuric acid, Corros. Sci., 46(2004), 387-403.
  30. C. Giacomelli, C.Giacomelli, M. F Amadori, V.Schmidt, A.Spinelli, Inhibitor effect of succinic acid on the corrosion resistance of mild steel: electrochemical, gravimetric and optical microscopic studies, Mater. Chem. Phys., 83(2004), 124-128.
  31. S. Ferreira, C. Giacomelli, F. C.Giacomelli, A. Spinelli, Evaluation of the inhibitor effect of L-ascorbic acid on the corrosion of mild steel, Mater. Chem. Phys., 83(2004), 129-134.
  32. E. F. El Sherbini, Effect of some ethoxylated fatty acids on the corrosion behaviour of mild steel in sulphuric acid solution, Mater. Chem. Phys., 60(1999), 286-290.
  33. S. Morad, Inhibition of iron corrosion in acid solutions by Cefatrexyl: Behaviour near and at the corrosion potential, Corros. Sci., 50(2008), 436-448.
  34. A. Quraishi, J. Rawat, M. Ajamal, Dithiobiurets: a novel class of acid corrosion inhibitors for mild steel, J. Appl. Electrochem., 30(2000), 745-751.
  35. Abdallah, Antibacterial drugs as corrosion inhibitors for corrosion of aluminum in hydrochloric acid solution, Corros. Sci., 46(2004), 1981-1996.
  36. A. Kumar, A. S. Kumar, S. R. Kumar, Corrosion inhibition Of mild steel in 0.5 M H2SO4 by 1-(2-methyl-4-(2-methylphenyldiazenyl) phenyl) azonapthalen-2-Ol, Am. J. Eng. Res., 2(2013), 17–22.
  37. K. Shukla, M. A. Quraishi, Effect of some substituted anilines-formaldehyde polymers on mild steel corrosion in hydrochloric acid medium, J. Appl. Polym. Sci., 124(2012), 5130-5137.
  38. Tang, A study of the polarisation techniques for corrosion rate measurement in a steel concrete system, 9th Int. Conf. Durab. Build. Mater. Components, no. Elsener 1995(2002), 17-20.
  39. Dwivedi, P. K. Bharti, S. K. Shukla, An overview of the polymeric materials that can be used to prevent metal corrosion: A review, J. Turkish Chem. Soc. A: Chem., 8(2021), 863-872.
  40. Branzoi, A. Băran, A. Ludmila, E. Alexandrescu, The inhibition action of some organic polymers on the corrosion carbon steel in acidic media, Chem. Pap., 74(2020), 4315-335.
  41. Branzoi, V. Branzoi, Investigation of some nonionic surfactants as corrosion inhibitors for carbon steel in sulfuric acid medium, Int. J. Electrochem. Sci., 12(2017), 7638-7658.
  42. P. Chakravarthy, K. N. Mohana, C. B. P. Kumar, Corrosion inhibition effect and adsorption behaviour of nicotinamide derivatives on mild steel in hydrochloric acid solution, Int. J Ind. Chem., 5(2014), 19-27.
  43. F. Sabirneeza, A. Rahiman, S. Sethumanickam, Corrosion inhibition, adsorption and thermodynamic properties of poly(vinyl alcohol-cysteine) in molar HCl, Ara. J. Chem., 10(2017), S3358-S3366
  44. Schorr, J. Yahalom, The significance of the energy of activation for the dissolution reaction of metal in acids, Corros. Sci., 12(1972), 867-868 .
  45. Bayol, A. A. Gurten, M. Dursun, K. Kayakirilmaz, Adsorption behaviour and inhibition corrosion effect of sodium carboxylmethyl cellulose on mild steel in acidic medium, Acta Phy. Chim Sin., 24(2008), 2236–2242.
  46. Naqvi, A. R. Saleemi, S. Naveed, Cefixime: a drug as efficient corrosion inhibitor for mild steel in acidic media, electrochemical and thermodynamic studies, Int. J. Electrochem. Sci., 6(2011), 146-161.
  47. Szauer, A. Brandt, On the role of fatty acid in adsorption and corrosion inhibition of iron by amine—fatty acid salts in acidic solution, Electrochim. Acta, 26(1981), 1253-1256.
  48. A. Farag , M. R. Noor El-Din, The adsorption and corrosion inhibition of some nonionic surfactants on API X65 steel surface in hydrochloric acid, Corros. Sci., 64(2012), 174-183.
  49. E. Ebenso, Synergistic effect of halide ions on the corrosion inhibition of aluminium in H2SO4 using 2-acetylphenothiazine, Mater. Chem. Phys., 79(2003), 58-70.
  50. E. Ebenso, I. B. Obot, Inhibitive properties, thermodynamic characterizationand quantum chemical studies of secnidazole on mild steel corrosion in acidic medium, Int. J. Electrochem. Sci., 5(2010), 2012-2035.
  51. S. Morad, Effect of sulfur-containing amino acids on the corrosion of mild steel in sulfide-polluted sulfuric acid solutions, J. Appl. Electro. Chem., 37(2007), 1191-1200.
  52. K. Singh, S. K. Shukla, M. A. Quraishi, Corrosion behavior of mild steel in sulphuric acid solution in presence of ceftazidime, Int. J. Electrochem. Sci., 6(2011), 5802-5814.
  53. Yesudass, L. Olasunkanmi, I. Bahadur, M. M. Kabanda, I. Obot, E .E. Ebenso, Experimental and theoretical studies on some selected ionic liquids with different cations/anions as corrosion inhibitors for mild steel in acidic medium, J. Taiw. Ins. Chem. Engg., 64(2016), 252-268.
  54. H. Madkour, Experimental and computational studies on the inhibition performances of benzimidazole and its derivatives for the corrosion of copper in nitric acid, Int. J. Ind. Chem., 7(2016), 195-221.
  55. P. Hanza, R. Naderi, E. Kowsari, M. Sayebani,Corrosion behavior of mild steel in H2SO4 solution with 1,4-di [1′-methylene-3′-methyl imidazolium bromide]-benzene as an ionic liquid, Corros. Sci., 107(2016), 96-106.
  56. S. K. Shukla, A. K. Singh E. E. Ebenso, Pharmacutically active compound as Corrosion Inhibitior for mild Steel in acidic medium, Int. J. Electrochem. Sci., 6(2019), 4276-4285.